The neural crest offers a unique model system to study cell migration mechanisms during vertebrate embryogenesis since migrating cells are accessible to in vivo time-lapse imaging and manipulation. We recently discovered by single cell profiling that lead cells of neural crest migratory streams express a distinct set of genes. By combining agent-based modeling and experiment, we are testing the function of novel genes for their role in cell invasion. I will discuss the function of two of these genes in the context of our current cell-induced gradient model of neural crest cell migration.

Paul Kulesa is director of imaging at the Stowers Institute for Medical Research.

Please join us for refreshments before the talk, 3:30-4p. The talk is 4-5p. Both the reception and the talk will be in the PIMS 4th-floor lounge, ESB 4133.